임플란트 주위 골 결손 부위에 Choukroun’s Platelet-rich-fibrin와 실크 분말 복합 이식재 사용
Effect of Combination Graft of Choukroun’s Platelet-rich-fibrin with Silk Fibroin Powder in the Peri-implant Defects
장은식, 이형석, 이희성, 이희종, 박기유, 박영욱, 윤연진, 홍순민, 박준우,
소속 상세정보
장은식 ( Jang Eun-Sik ) - 한림대학교 의학과 대학원
이형석 ( Lee Hyung-Seok ) - 한림대학교 의학과 대학원
이희성 ( Lee Hee-Sung ) - 한림대학교 의학과 대학원
이희종 ( Lee Hee-Jong ) - 한림대학교 의학과 대학원
박기유 ( Park Ki-Yu ) - 한림대학교 의학과 대학원
박영욱 ( Park Young-Wook ) - 강릉원주대학교 치과대학 구강악안면외과학교실
윤연진 ( Yoon Youn-Jin ) - 한림대학교 의과대학 강동성심병원 구강악안면외과학교실
홍순민 ( Hong Soon-Min ) - 한림대학교 의과대학 강동성심병원 구강악안면외과학교실
박준우 ( Park Jun-Woo ) - 한림대학교 의과대학 강동성심병원 구강악안면외과학교실
KMID : 0360120110330020103
Abstract
Purpose: Choukroun’s platelet-rich-fibrin (PRF) is composed of platelets, white blood cells and fibrin matrix. It does not induce enough bone formation by itself but it can improve bone formation with calcium. Silk fibroin does not cause inflammatory reactions because it is bio-compatible and degradable. The purpose of this study was to exam the bone formation when a combination of Choukroun’s PRF and silk fibroin was used.
Methods: In this study, cell reactions to silk powder with differing molecular weights was first tested to select the appropriate silk powder. Then we applied these bone graft materials on defects of skull and in a peri-implant bony defect model in New Zealand rabbits. The results between the experimental and control s (non-grafted) group were analyzed.
Results: The small sized silk fibroin powder showed increased cellular proliferation for bone-regeneration. There was no statistically significant difference between the experimental group and the control group at 6 weeks, but more new bone formation was observed in the combination graft group at 12 weeks (P＜0.05). And in the dental implant model, the combination bone graft group showed much improved torque test results, which was statistically significant. Histomorphometric analysis showed more regenerated cortical bone and a higher mean bone to implant in the experimental group. Both were statistically significant.
Conclusion: The combination graft of Choukroun’s platelet-rich-fibrin (PRF) and silk fibroin powder can successfully restore the bony defects in a skull defected model and a peri-implant bony defects model.
키워드
Platelet rich fibrin; Silk; Graft; Bone; Implant
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